苏炳添腿长:Charles A. Janeway, Jr.

Family, friends, and colleagues representing Yale University andthe international immunology community gathered recently toremember past AAI president Charles Janeway, Jr., (AAI ?, whopassed away in April following a long illness.

The May memorial service was held at New Haven's UnitedChurch on the Green, reports AAI President Laurie Glimcher, M.D.,who attended on behalf of the AAI Council.

Courtesy of Yale University, the following obituary was publishedon the Yale website.

In Memoriam: World Renowned Yale Immunobiologist and"Father of Innate Immunity," Charles Janeway

New Haven, Conn. -- Charles Alderson Janeway, Jr., M.D.,professor of immunobiology at the Yale University School ofMedicine and a Howard Hughes Medical Institute investigatordied on April 12 at age 60 in New Haven after a long illness.

Janeway was one of the leading immunologists of his generationwhose ideas formed many of the concepts that are the basis ofimmunology today. He made major contributions to ourunderstanding of T lymphocyte biology. He is renowned for hisrecent work on innate immunity, which is the body's first line ofdefense against infection.

With brilliant insight, Janeway predicted in 1989 that patternrecognition receptors would mediate the body's ability torecognize invasion by microorganisms. This striking predictionwas made first on theoretical grounds and subsequently incisiveexperimental work in his laboratory established the underlyingmechanisms. In this way, Janeway was one of the key fathers ofwhat has become the new field of innate immunity, perhaps themost exciting area of immunologic research in recenttimes."Charlie's contributions to immunobiology have beenprofound," said Yale School of Medicine Dean David Kessler,M.D. "Charlie Janeway will be remembered as a toweringintellect and leading citizen of this Medical School and theUniversity. We shall all miss him."

Born in Boston on February 5, 1943 to Charles A. and ElizabethB. Janeway, Janeway was raised in Weston, Mass., where heformed several lifelong friendships. He was educated at PhillipsExeter Academy in Exeter, N.H., and Harvard College, where hegraduated summa cum laude in 1963 with a bachelor's degree inchemistry. His interest in medicine was inspired by his parents:his father was Physician-in-Chief at Boston Children's Hospitalfrom 1946 to 1974, and his mother was a social worker at theBoston Lying-In Hospital.

By earning his medical degree from Harvard Medical School in1969, Janeway joined a long family line of prominent physicians.In addition to his father, his grandfather, Theodore C. Janeway,was the first full-time professor of medicine at the Johns HopkinsUniversity School of Medicine,and his great-grandfather,Edward G. Janeway, was the NewYork City Health Commissioner.

Janeway trained in basic-scienceresearch with Hugh McDevitt atHarvard, John Humphrey at theNational Institute for MedicalResearch in England, and withRobin Coombs at CambridgeUniversity in England. Hecompleted an internal medicineinternship at the Peter BentBrigham Hospital in Boston. Following five years of immunologyresearch at the National Institutes of Health in Bethesda, Md.,under William E. Paul, and two years at Uppsala University inSweden under Hans Wigzell, he joined the Yale faculty in 1977. In1983 he was promoted to Professor of Pathology and in 1988 hebecame one of the founding members of the newly created Sectionof Immunobiology at Yale University School of Medicine.

During his career, Janeway published more than 300 scientificpapers. He was the principal author of the acclaimed textbookImmunobiology: The Immune System in Health and Disease,now in its 5th edition. He was elected to the National Academy ofSciences and won a number of awards, including the AmericanAssociation of Immunologists Lifetime Achievement Award andthe Avery-Landsteiner Award, the highest honor of the GermanSociety of Immunology. He served on the board of directors ofseveral research institutes, including the Trudeau Institute, theJackson Laboratory and the Federation of American Societies forExperimental Biology. He was president of the AmericanAssociation of Immunologists from 1997-1998.

Janeway took pride in training medical students, undergraduateand graduate students, and post-doctoral fellows, many of whomare now professors in immunology departments around theworld. A gifted teacher, his lively lectures won him Yale'sBohmfalk Teaching Award in 1991.

Friends, colleagues and family remember him as "Charlie," onewho loved sharing outdoor activities with his family, especiallyhiking and fly-fishing in New York's Adirondack Mountains andsailing the waters off of Cape Ann, Massachusetts. He treasuredthe poetry of Robert Frost and illustrated a number of Frost'spoems with linoleum block prints.

Janeway is survived by his wife and colleague of 25 years, H. KimBottomly, also a professor of immunobiology at the Yale School ofMedicine; three daughters: Katherine A. Janeway, M.D., ofCambridge, Mass., and Hannah H. Janeway and Megan G.Janeway, both of New Haven; three sisters: Anne Janeway ofMarlboro, Vt., Elizabeth J. Gold of Toronto, Ontario, andBarbara B. Janeway of Newfields, N.H.; three nephews and oneniece; and one grandnephew and one grandniece.

-- Yale University

(http://www.aai.org/prog_eb2004/janeway.html)